TH1834 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TH1834 diHClide (TH-1834, TH 1834) 是一种新型强效特异性组蛋白乙酰转移酶 Tip60 抑制剂。

TH1834 dihydrochloride (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor; induces apoptosis in breast cancer cell lines with more cytotoxicity than staurosporine; increases the γH2AX foci in the cancer cell lines PC-3 and DU-145 combined with IR; induces apoptosis and increases unrepaired DNA damage in breast cancer cells.

Cell Viability Assay Cell Line:MCF7 cells Concentration:0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM Incubation Time:1 hour Result:Significantly reduced the viability of MCF7 cells.Cell Cytotoxicity Assay Cell Line:MCF7 cells Concentration:0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM Incubation Time:1 hour Result:Highly significant increase in cytotoxicity at all concentrations used.Western Blot Analysis Cell Line:MCF7 cells Concentration:500 μM Incubation Time:1 hour Result:Marked caspase 3 activation was observed in MCF7 cells in an independent assay.

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TH-1834 | TH 1834

Chromatin/Epigenetic

HAT

HAT

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2108830-09-5

641.638

C33H42Cl2N6O3

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (155.85 mM)

O=C(O)CN1N=C(C2=CC=C(CN(CCC3=CC=CC=C3)CCCCOC4=CC=C(CN5CCCC5)C=C4)C=C2)N=N1.[H]Cl

2-(5-(4-((phenethyl(4-(4-(pyrrolidin-1-ylmethyl)phenoxy)butyl)amino)methyl)phenyl)-2H-tetrazol-2-yl)acetic acid dihydrochloride

(-20℃)

With Ice Pack

≥ 2 years